Abstract: The forces of cryogenic vessels pipes are complicated. The pipes also are the weak parts of cryogenic vessel. In order to ensure the cryogenic vessels of space launching site operate safely and reliably,this paper presents the design contents (including the structural requirements,the main analysis and checking on pipeline function,the flexible pipeline computing and result determination) according to the using feature of the cryogenic vessels of space launching site. For an example of the design of a pipe with 50mm diameter,the pipe stress analysis was conducted by analysis software. It is proposed to increase the flexibility of the pipe according to the comparisons among the pipe occupation space,the pipe stress value and the force producing by the pipe to cryogenic vessel nozzles. Base on the importance and the complexity of the pipe design for the cryogenic vessels of space launching site,it is suggested to take measure to ensure the pipe structure reasonable and reliable.