Abstract: It is very important to study the fast leak location method for the on-orbit spacecraft and astronaut safety. The space station cabin was the studying object. And the method research was based on aero-acoustic theory to analysis leak ultrasonic resource distribution in the space. And this method was researched by designing new complex sensor of array ultrasonic sensor and video sensor and studying the video guide leak location arithmetic method. Then,it was validated that this method was speedy and effective by the experiments research. The research conclusions indicate that the video guide leak location method can guide the leak orientation and find the leak position. The result can lead handler to the main leak orientation find the leak to reduce the detection time. And the method location accuracy is ±20 mm. This method is very fit for the space station huge cabin leak detection on orbit to improve efficiency. It is very significative for spacecraft leak detection operation on orbit.