Abstract: For half a century,manned lunar landing has become one of the primary goals for the power country in spaceflight since humans first set foot on the moon.Unlike traditional lunar exploration missions,the thermal control system will face severe challenges in midium and long-term manned lunar landing mission.Conventional thermal control technology can no longer meet the demand for high-power heat rejection in high-temperature environments,and it is urgently needed develop a new generation heat-pump-based thermal control technology.Based on the task constraints and heat rejection requirements of the lunar habitable mobile platform,this paper proposes the design goals and operating conditions of the heat pump,and it compares the energy efficiency ratio(COP)of 15 common refrigerants and 4 thermal cycle forms through theoretical analysis,and finally it is proposed that the single-stage compression heat pump with R134a is the best choice,which provides design support for future manned lunar landing projects.