Abstract: Cryogenic systems play an important role in space applications such as astronomical devices and deep space exploration.Lowering the refrigeration temperature can improve the measurement accuracy of the detection system,thereby obtaining a higher signal-to-noise ratio.An integrated system based on pulse tube cooler and cryogenic loop heat pipe is designed and manufactured.The integrated connection design is adopted and the installation interface is omitted.Two 35 K pulse tube coolers are used as heat sinks for two sets of 35 K neon cryogenic loop heat pipes.The heat pipe evaporators can be coupled to the same detector to realize the backup redundancy design of the system.A low-temperature heat-insulating cold shield is designed to reduce the parasitic heat leakage in the surrounding environment,and the 80 K pulse tube refrigerator is used as the cold shield heat sink.The loop heat pipe of the integrated system can realize the heat transmission of about 2 W,with a maximum transmission distance of 510 mm,which provides technical support for future deep space exploration technology.