Abstract: The problem welding of titanium and iron dissimilar metal structure was analyzed.According to the welding process and feature of diffusion welding,the diffusion welding procedure of Ti6Al4V titanium alloy plate and 00Cr18Ni13 stainless steel net was detailedly investigated.The results showed the occurrence of brittle intermetallics phase were inevitable in joints if intermediate layer stuffs cannot be introduced.By means of optimization technical parameter of diffusion welding,the brittle intermetallics phase decreases to the least degree in the weld.The effect of the diffusion welding is satisfactory.