Abstract: Thermoacoustic cooler driving by sound is the optimal project for developing of subminiature cryogenic technology. A thermoacoustic refrigeration device （TAR）includes an acoustic wave generation device arranged directed to the channel of a hollow tube, and a regenerator provided at a predetermined position in the channel of the tube. A temperature gradient is obtained across the regenerator by an acoustic wave emitted from the acoustic wave generation device. Therefore, a TAR realizing a gas Stirling cycle approximating the Carnot cycle which is an ideal gas cycle, and realizing simplification of the structure and high efficiency of the device is provided.